Effect of Royal Jelly on Sperm Parameters in Aluminum-Treated Male Rats

  • Abdul-Hadi Abbas Hadi
  • Hussein Bahaa Deaibil

Abstract

Background: Aluminum (Al) metal is abundantly present in the earth’s crust. Aluminum is present in many manufactured foods and medicines and is also added to drinking water during purification purposes, and this has allowed its easy access into the body. Aluminum has been proposed as an environmental factor that may contribute to some diseases. Different forms of aluminum are environmental xenobiotics that induce free radical-mediated cytotoxicity and reproductive toxicity. Royal jelly is a substance produced by worker honey bees. If fed to an ordinary female bee in the larval stage, royal jelly will transform her into the queen bee. Scientific research on royal jelly has revealed that it benefits sexual performance.

Methods and Materials: Fifty adult male albino rats were used in this study. They were randomly divided into five groups. The first group served as control group (negative group). The second group was received 20 mg AlCl3 /kg body weight (positive group). The other groups were received the same dose of AlCl3 and subdivided into three groups according to the concentration of royal jelly (RJ). Three concentrations of RJ were investigated (50, 100 and 200 mg/kg). All treated doses were given orally by gastric intubation and the experiment was continued daily for 60 days. This study included the studying the sperm parameters in tail of epididymis, measuring the values of some hormones including testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) and  estimate the level of malondialdehyde (MDA) in blood serum.

Results: The supplementation of aluminum-treated animals with the royal jelly resulted in an appreciable improvement in all the studied reproductive parameters, hormonal level and MDA. Moreover, increasing degree of amelioration was in correlation with the amount of progressive concentrations of royal jelly.

Conclusion: This study showed that RJ has alleviating effect and protective role in the condition of aluminium -induced oxidative stress.

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Published
2020-04-08
Section
Original Articles